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微纳电子学系王玮教授课题组在超大体积通量液态活检领域取得系列重要进展

    液态活检已经成为癌症精准医疗的关键技术。目前液态活检方法主要以血液中循环肿瘤细胞(Circulating tumor cell, CTC)及其衍生生物靶标为检测目标;而其它体液(如肺泡灌洗液)中原发灶指向性更强的脱落肿瘤细胞(Exfoliated tumor cell, ETC)也和肿瘤进展具有紧密相关性,是液态活检的重要对象之一, 对癌症精准医疗具有更高的应用价值。目前已报道的液态活检技术体积通量低,无法应用于大体积体液中脱落肿瘤细胞的快速检出;而对于最有望获得高体积通量液态活检方法的微孔滤膜技术,目前已报道的微孔滤膜的孔−孔间距大、孔隙率低,可实现的体积通量也无法满足复杂临床体液样品的高体积通量液态活检的需求。     针对上述超大体积通量液态活检方法的关键问题,北京大学微纳电子学系王玮教授课题组基于聚对二甲苯微机电系统(Parylene C MEMS)工艺开发了一种具有高孔隙率(最高可达91.37%)、大面积(大于20 mm×20 mm)的2.5维柔性微孔滤膜。整张滤膜的大面积和小厚度(~10 μm)体现二维特点,而孔−孔间距处的大厚/宽比(10 μm/<4 μm)使局部呈现三维特点;滤膜整体呈现2.5维特点。实验证明,此2.5维柔性微孔滤膜在无需额外压力、完全重力驱动下,实现了超高体积通量:水性样品>117 mL/min,未稀释全血>17 mL/min(文献报道最高记录为2 mL/min)。相关研究于2018年6月以“2.5-Dimensional Parylene C […]

Featured in a recent issue of Lab on a Chip

Congratulations! Yaoping’s work “A high-throughput liquid biopsy platform based on a 2.5D micropore-arrayed filtration membrane” is featured in a recent issue of Lab on a Chip! […]

Wish them promising futures! The farewell party finished successfully

Lingqian Zhang, Xiaolong Rao, Yudan Pi, Xiaofan Zhao, Yuanjian Wu, Haida Li, Yechang Guo and Han Xu graduated from Wangwei Group. We held the farewell […]

Congratulations! Lingqian Zhang Finished Dissertation Defense

Dissertation defense meeting for Ph.D. candidates from EECS, Peking University was held in Micro/Namo Electronics Building on May 31st, 2018. Lingqian Zhang directed by prof. […]